Exercise Physiology
Maryam Belbasi; Asieh Abbassi Daloii; Ahmad Abdi
Abstract
Aim: Type 2 diabetes and obesity are associated with changes in the body's metabolism, which is a determining factor in the development of insulin resistance. The aim of this study was to investigate the effect of six weeks high-intensity interval training on Vascular endothelial growth factor A (VEGF-A) ...
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Aim: Type 2 diabetes and obesity are associated with changes in the body's metabolism, which is a determining factor in the development of insulin resistance. The aim of this study was to investigate the effect of six weeks high-intensity interval training on Vascular endothelial growth factor A (VEGF-A) and Adipocyte fatty acid-binding protein (A-FABP) levels of adipose tissue in type 2 diabetic obese rats. Method: To implementation of this experimental research, 32 obese male wistar rats (weight 320±20 gr) randomly were divided into 4 groups including obese control, shem (obese), obese diabetic, obese diabetic - high-intensity interval training. Intraperitoneal injection of nicotinamide amide-streptozotocin was used to induction type 2 diabetes. high-intensity interval training program was performed 4 days a week for six weeks. VEGF-A and A-FABP levels in rat adipose tissue were measured using by ELISA kit. Results: the VEGF-A level in adipose tissue in the obese diabetic group was significantly lower than the obese control group (P=0.001). Also, A-FABP (P=0.001) and insulin resistance (P=0.004) was significantly higher in the obese diabetic group than the obese control groups. High-intensity interval training was associated with significant increase of VEGF-A and decrease A-FABP levels in adipose tissue and insulin resistance in obese diabetic rats (P=0.001). Conclusion: It seems that high-intensity interval training can help improve adipose tissue metabolic parameters and insulin resistance in obese diabetic rats.
